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KMID : 0604520180440010081
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 1 p.81 ~ p.87
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Optical Clearing Agent Decreases Scattering of Stratum Corneum and Modulates Physical Properties of Corneocytes by Hydration
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Jun Seung-Hyun
Yeom Jun-Seok
Ahn Byung-Jun
Park Sun-Gyoo
Lee Cheon-Koo
Lee Seol-Hoon
Kang Nae-Gyu
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Abstract
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The objective of this article is to provide analytical tools for the scattering of stratum corneum (SC) and to check whether the optical clearing agents (OCAs) could be applied in optics affecting the scattering reduction. Dark field images of tape striped corneocyte separates scattered light of the SC from others in vitro. Several optical clearing agents were tested to reduce the scattering. Physical properties of SC such as water contents, keratin configuration and volume after OCAs treatment were investigated by FT-IR and 3D laser microscope. Several reducing sugars, monomeric sugars, sugar alcohol, and hyaluronic acid, which were used as humectants in cosmetic field, also reduced scattering. However, unlike dehydration in optics, water penetrated into the keratin in SC and scattering was decreased at low concentration of OCAs. In that condition, the volume of corneocyte was increased and stiffness seemed to decrease. The analyzing of tape-stripped SC, showed the change of optical and physical properties of corneocyte by optical clearing agents. The hydration of SC layer by optical clearing agents decreased the scattering of corneocyte and thus improved the skin appearance and moisturizing effect, which are important benefits in the cosmetic field and could provide new possibility to develop skin care study targeting at SC.
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KEYWORD
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skin scattering, optical clearing, skin hydration, keratin, stratum corneum
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